Knowledge Centre

Q: What is a scaffold?

A scaffold consists of an architecture of materials, precisely designed to serve a function. As described by many, “form follows function”. Osteopore scaffolds are designed based on this principle.

The unique laydown pattern of Osteopore scaffolds creates interconnected pores in 3D. Interconnectivity is very important to ensure sufficient nutrient flow.

In addition, these unique 3D spaces create space for tissue ingrowth to improve host-material interactions. Osteopore 3D scaffolds are designed with an end-goal in mind: to encourage tissue regeneration, and to do that, an interconnected, porous 3D scaffold is required.

Q: What do you mean by a “bioresorbable scaffold”?

Bioresorbable refers to the act of being absorbed by the body, without adverse events. To understand this better, we need to understand how our body works. During the implantation of foreign materials into our body, a period of inflammation follows, and depending on the interactions between the material and our immune system, inflammation may be acute, or chronic. To understand inflammation more, please click here**. The more irritable the implanted material is, the more likely inflammation will be prolonged.

By having a foreign material that is precisely designed to slowly be absorbed by our body while at the same time encouraging tissue regeneration due to its unique architecture, a bioresorbable scaffold may be significant advantages over their non-resorbable counterparts. More attractively, at the end of the regeneration process, there will be no foreign materials within the body, only your own tissue remains.

Q: On inflammation

**Inflammation is not undesirable; prolonged inflammation is undesirable. In fact, inflammation helps the healing process. According to Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, “For wounds to heal we need controlled inflammation, not too much, and not too little,"

"It's been known for a long time that excess anti-inflammatory medication, such as cortisone, slows wound healing. This study goes a long way to telling us why: insulin-like growth factor and other materials released by inflammatory cells helps wound to heal." – taken from http://www.medicalnewstoday.com/articles/203538.php **

Q: Are Osteopore products safe?

Yes! Our products have been used in clincics for over 10 years and counting, and we do not have records of adverse events.

All our products are regulated strictly, and manufactured in compliance to various standards.

Q: How is a foreign material bioresorbed?

The process of bioresoption begins with the degradation of the implant, which may be initiated by many factors, including local pH conditions, enzymatic activities, and macrophage activation, all of these which make up the inflammatory environment.

At the onset of degradation, small segments of the implant will be slowly removed, and depending on the chemical nature and compatibility of these degradation by-products, they may be taken up into the body’s important, natural metabolic cycle known as the citric acid cycle.

Above Image taken from Wikipedia.

Q: Is polycaprolactone (PCL) resorbable?

Yes! PCL is resorbable, its final degradation products are carbon dioxide and water.

Q: Indication for use for osteopore products

The Osteopore PCL Scaffold™ is a bone void filler. The shape of the Osteopore PCL Scaffold™ conforms to the defect, thus maximizing direct contact with viable host bone. It is intended for use in the repair of neurosurgical burr holes, craniotomy cuts and other cranial defects.

It is also used in the augmentation or restoration of bony contour in the craniofacial skeleton. As long as your patients present with the mentioned defects, Osteopore PCL Scaffold™ may be suitable for them.

Q: Customization

Osteopore is able to meet your requirements for customization.

Please contact our technical development team at osteopore@outlook.sg if you need customized scaffolds for your patients.

Osteopore has a strong research team that has a solid foundation in medical device design. We are always keen to develop new products that benefit patients. Please check back for updates on our latest/upcoming products.